Under Adjust time limits and flashing visuals, select:
An interval for How long should Windows notification dialog boxes stay open from 7 seconds to 5 minutes by pressing ALT+X and the arrow keys.
Select Save by pressing ALT+S.
Make Items on the Screen Appear Larger (Magnifier)
Magnifier, the magnification program built into Windows Vista, enables you to choose magnification levels from 2 to 16 times the original, and to choose to track the mouse, the keyboard, or text editing.