Neonatal Intensive Care Drug Manual




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Phenobarbitone


Revision Date : 16-11-2020

Approved: TC, KOH




Alert

S4 – High risk medicine.

Phenobarbital is reported in mg/L. To convert to micromol/L, multiply by 4.306.



Indication

  1. Treatment of neonatal seizures.

  2. Initial treatment of non-opioid neonatal abstinence syndrome (NAS).

  3. Add-on treatment of opioid NAS uncontrolled by morphine at maximum dose (if 3 consecutive NAS scores average ≥ 8 or 2 consecutive NAS scores average ≥12).

  4. Treatment of hyperbilirubinaemia (unclear role).

  5. Treatment of cholestasis (unclear role).

  6. Preparation for liver scintigraphy (unclear role).

Action

Enhances inhibitory neurotransmission via activation of GABA receptor.


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Neonatal Intensive Care Drug Manual

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