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Neonatal Intensive Care Drug Manual
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| bet | 2/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Drug Name
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Revision Date : 27/04/2021
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Approved : AK, JD
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Indication :
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A brief description of the uses for the chosen drug
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Dose :
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Single Dose amount
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Interval :
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Dosage interval or number of doses per day
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Route :
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Oral, intravenous, intra-arterial or other routes available
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Total Daily Dose :
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Maximum recommended daily dosage
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Comments :
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Description of action, precautions, side effects etc.
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Supplied as :
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Company or trade name is not usually recorded and should not be used in prescriptions. Amount usually found in supplied units.
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Dilution :
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Instructions for appropriate dilution. May differ from that recommended by suppliers because has been adjusted for use in small babies.
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Stability :
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Refers to how long drug can be used after being reconstituted or diluted.
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Storage :
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Usual method and place of storage - cupboard, fridge, freezer etc.
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Incompatibility :
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Drug and diluent incompatibilities, comments on whether can be given mixed with other drugs or solutions.
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Serum Levels :
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Therapeutic range - if known
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Acetylcysteine for Mucolysis |
Revision Date : December 2020
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Approved : TC, KOH
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Alert
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Also known as N-acetylcysteine (NAC).
Refer to acetylcysteine intravenous for paracetamol overdose.
Safety data for acetylcysteine as a mucolytic agent in newborn infants is limited and the dosage recommendation was on the basis of consensus.
Injection preparations are safe to use as oral preparation.
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Indication
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Meconium ileus secondary to cystic fibrosis
Meconium-related ileus of preterm infants
Distal intestinal obstruction secondary to cystic fibrosis
Gastric or intestinal milk curd obstruction (lactobezoar)
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Action
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Reduces the viscosity of mucus by cleaving disulphide bonds in the mucoprotein
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Drug type
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Mucolytic agent
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Trade name
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DBL Acetylcysteine Injection Concentrate
Acetadote Concentrated Injection (solution for infusion)
Acetylcysteine-Link Concentrate for infusion
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Presentation
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DBL Acetylcysteine Injection Concentrate 20%; 200 mg/mL ampoule
Acetadote Concentrated Injection (Solution for infusion) 20%; 200 mg/mL vial
Acetylcysteine-Link Concentrate for infusion 20%; 200 mg/mL ampoule
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Dosage
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Intragastric
Meconium ileus: 400 mg/dose (4 mL/dose of acetylcysteine 10%) (range 100–500 mg/dose, 1–5 mL/dose of acetylcysteine 10%) 6–8 hourly5. Acetylcysteine 10% = 100 mg/mL
Distal intestinal obstruction secondary to CF in 1–3-month old: 400 mg/dose (8 mL of acetylcysteine 5% (50 mg/mL) daily29. Acetylcysteine 5% = 50 mg/mL
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