Indication :
|
A brief description of the uses for the chosen drug
|
Dose :
|
Single Dose amount
|
Interval :
|
Dosage interval or number of doses per day
|
Route :
|
Oral, intravenous, intra-arterial or other routes available
|
Total Daily Dose :
|
Maximum recommended daily dosage
|
Comments :
|
Description of action, precautions, side effects etc.
|
Supplied as :
|
Company or trade name is not usually recorded and should not be used in prescriptions. Amount usually found in supplied units.
|
Dilution :
|
Instructions for appropriate dilution. May differ from that recommended by suppliers because has been adjusted for use in small babies.
|
Stability :
|
Refers to how long drug can be used after being reconstituted or diluted.
|
Storage :
|
Usual method and place of storage - cupboard, fridge, freezer etc.
|
Incompatibility :
|
Drug and diluent incompatibilities, comments on whether can be given mixed with other drugs or solutions.
|
Serum Levels :
|
Therapeutic range - if known
|
Alert
|
Also known as N-acetylcysteine (NAC).
Refer to acetylcysteine intravenous for paracetamol overdose.
Safety data for acetylcysteine as a mucolytic agent in newborn infants is limited and the dosage recommendation was on the basis of consensus.
Injection preparations are safe to use as oral preparation.
|
Indication
|
Meconium ileus secondary to cystic fibrosis
Meconium-related ileus of preterm infants
Distal intestinal obstruction secondary to cystic fibrosis
Gastric or intestinal milk curd obstruction (lactobezoar)
|
Action
|
Reduces the viscosity of mucus by cleaving disulphide bonds in the mucoprotein
|
Drug type
|
Mucolytic agent
|
Trade name
|
DBL Acetylcysteine Injection Concentrate
Acetadote Concentrated Injection (solution for infusion)
Acetylcysteine-Link Concentrate for infusion
|
Presentation
|
DBL Acetylcysteine Injection Concentrate 20%; 200 mg/mL ampoule
Acetadote Concentrated Injection (Solution for infusion) 20%; 200 mg/mL vial
Acetylcysteine-Link Concentrate for infusion 20%; 200 mg/mL ampoule
|
Dosage
|
Intragastric
Meconium ileus: 400 mg/dose (4 mL/dose of acetylcysteine 10%) (range 100–500 mg/dose, 1–5 mL/dose of acetylcysteine 10%) 6–8 hourly5. Acetylcysteine 10% = 100 mg/mL
Distal intestinal obstruction secondary to CF in 1–3-month old: 400 mg/dose (8 mL of acetylcysteine 5% (50 mg/mL) daily29. Acetylcysteine 5% = 50 mg/mL
|
