• Drug interactions
  • Compatibility
  • Incompatibility Fluids: No information Stability
  • Storage Injection: Store at room temperature. Protect from light. Excipients
  • Neonatal Intensive Care Drug Manual




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    Contraindications

    Hypersensitivity to acetylcysteine or any component of the preparation

    Precautions

    Do not use if intestinal perforation is suspected

    Abnormal liver and/or renal function

    Caution in asthma and bronchospasm

    Acetylcysteine is not compatible with rubber and some metals, particularly, iron, copper and nickel. Can be used with silicone and plastic.



    Drug interactions

    Glyceryl trinitrate: Increased risk of hypotension

    Adverse reactions

    Flushing, pruritus and urticarial reactions reported.

    Hypersensitivity reactions, vomiting, nausea, hypernatremia, hepatotoxicity, mucosal injury and haemorrhage.



    Compatibility

    Fluids: DBL Acetylcysteine Injection Concentrate and Acetylcysteine-Link Concentrate: Glucose 5%, sodium chloride 0.9%

    Acetadote Concentrated Injection: Glucose 5%



    Incompatibility

    Fluids: No information

    Stability

    Extemporaneously prepared solutions of 1% and 10% acetylcysteine diluted with sodium chloride 0.9% are stable for up to 60 days when stored in plastic amber bottles at room temperature.24

    Acetadote Concentrated Injection is stable for 24 hours at 2 to 8°C after dilution.



    Storage

    Injection: Store at room temperature. Protect from light.

    Excipients

    DBL Acetylcysteine Injection Concentrate and Acetylcysteine-Link Concentrate for infusion: Disodium edetate, sodium hydroxide, water for injections.

    Acetadote Concentrated Injection (solution for infusion): Water for injections and sodium hydroxide for pH adjustment.26-28




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    Neonatal Intensive Care Drug Manual

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