Contraindications
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Hypersensitivity to acetylcysteine or any component of the preparation
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Precautions
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Do not use if intestinal perforation is suspected
Abnormal liver and/or renal function
Caution in asthma and bronchospasm
Acetylcysteine is not compatible with rubber and some metals, particularly, iron, copper and nickel. Can be used with silicone and plastic.
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Drug interactions
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Glyceryl trinitrate: Increased risk of hypotension
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Adverse reactions
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Flushing, pruritus and urticarial reactions reported.
Hypersensitivity reactions, vomiting, nausea, hypernatremia, hepatotoxicity, mucosal injury and haemorrhage.
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Compatibility
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Fluids: DBL Acetylcysteine Injection Concentrate and Acetylcysteine-Link Concentrate: Glucose 5%, sodium chloride 0.9%
Acetadote Concentrated Injection: Glucose 5%
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Incompatibility
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Fluids: No information
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Stability
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Extemporaneously prepared solutions of 1% and 10% acetylcysteine diluted with sodium chloride 0.9% are stable for up to 60 days when stored in plastic amber bottles at room temperature.24
Acetadote Concentrated Injection is stable for 24 hours at 2 to 8°C after dilution.
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Storage
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Injection: Store at room temperature. Protect from light.
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Excipients
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DBL Acetylcysteine Injection Concentrate and Acetylcysteine-Link Concentrate for infusion: Disodium edetate, sodium hydroxide, water for injections.
Acetadote Concentrated Injection (solution for infusion): Water for injections and sodium hydroxide for pH adjustment.26-28
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