Prostacyclin PGI2(Epoprostenol)




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Prostacyclin PGI2(Epoprostenol)


Revision Date : 29-10-2020

Approved: TCo, KOH




Indication :

Persistent pulmonary hypertension of the newborn unresponsive to usual ventilatory strategies, inhaled nitric oxide and appropriate inotropic support.

Dose :

Initial dose 2nanograms/kg/minute

Titrate to clinical effect increasing by 1-2nanogram/kg/min not faster than 15minutely.

Limited evidence for max dose for PPHN in neonates (UK guidance (BNF/NICE) state usual max 20nanograms/kg/min; rarely up to 40nanograms/kg/min)

Doses up to 80-150nanograms/kg/min used in adult and paediatric patients for chronic pulmonary arterial hypertension

Interval :

Continuous infusion only

Route :

I.V. (central venous line strongly recommended)

Total Daily Dose :




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