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Treatment of neonatal suspected sepsis
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| bet | 616/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
| Treatment of neonatal suspected sepsis: Two RCTs have compared the efficacy of vancomycin with other antibiotics in newborns with suspected sepsis.[8, 9] Deville et al 2003 [9] reported 63 neonates randomised 2:1 to linezolid (n = 43) or vancomycin (n = 20) with no significant difference in clinical cure rates (78% vs. 61%; P = 0.196). Ceriani Cernadas et al 2014 [8] reported 109 newborns randomised to cefazolin (52) or vancomycin (57) with no significant difference in rate of adequate outcome (no clinical signs, negative culture and normal laboratory test: cefazolin 92% versus vancomycin 86%) or mortality (cefazolin 7 (13.5%) versus vancomycin 11 (19.2%); p =0.45).
Gwee et al 2018 [5] compared intermittent intravenous (IV) dosing using the British Neonatal Formulary (BNF) dosage guidance versus continuous IV [loading dose of 15 mg/kg over 1 hour then continuous infusion). There was no difference in time to clearance of organism or mortality although this study was not powered to detect this.
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