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Neonatal Intensive Care Drug Manual
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| bet | 147/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Dexmedetomidine
Revision Date : 28-5-2020
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Approved : TC, KOH
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Alert
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Use only where cardiac monitoring and cardiorespiratory resuscitation equipment are available.
Dexmedetomidine is not FDA or TGA approved for use in children.
There are insufficient trial data evaluating the use of dexmedetomidine in newborn infants.
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Indication
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Sedation for agitated ventilated patients.
Adjunct therapy with inhalational anaesthesia for both perioperative and postoperative procedures.
Sedation with nerve blocking agents for surgical procedures.
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Action
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Centrally acting α2-agonist with sedative, anxiolytic, sympatholytic and analgo-sedative properties. Haemodynamic effects including transient hypertension, bradycardia and hypotension resulting from the drug’s peripheral vasoconstrictive and sympatholytic properties. Dexmedetomidine exerts its hypnotic action through activation of central pre- and postsynaptic α2-receptors in the locus coeruleus, inducing a state of unconsciousness similar to natural sleep, except patients remain rousable.[1, 2]
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Drug type
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Central Nervous System - Sedative, hypnotic - centrally acting α2-agonist
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Trade name
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Dexmedetomidine Mylan Concentrate for infusion
Dexmedetomidine Ever Pharma Concentrate for infusion
Dexmedetomidine Sandoz Concentrate for infusion
Dexmedetomidine-Teva Concentrate for infusion
Precedex Concentrate for infusion
Precedex Ready to Use Solution for infusion
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Presentation
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Dexmedetomidine Mylan Concentrate for infusion – 100 microgram/mL 2 mL vial.
Dexmedetomidine Ever Pharma Concentrate for infusion – 100 microgram/mL 2 mL, 4 mL, 10 mL vials; 50 microgram/mL 2 mL ampoule.
Dexmedetomidine Sandoz Concentrate for infusion – 100 microgram/mL 2 mL vial.
Dexmedetomidine-Teva Concentrate for infusion – 100 microgram/mL 2 mL vial.
Precedex Concentrate for infusion – 100 microgram/mL; 2 mL vial.
Precedex Ready to Use Solution for infusion – 4 microgram/mL; 20 mL vial; 4 microgram/mL 50 mL and 100 mL glass bottles.
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