Neonatal Intensive Care Drug Manual




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Bioavailability

The absorption was lower in infants <1 month of age than in older children. Administration of the drug with feeds considerably increased the absorption of erythromycin ethylsuccinate.15



References



1. Centers for Disease Control and Prevention. Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis, 2005. MMWR Recomm Rep. 2005 December 9, 2005 / 54(RR14);1-16.

2. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.

3. American Academy of Pediatrics (AAP). In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2012 Report of the Committee on Infectious Diseases. 29th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2012.

4. Altunaiji SM, Kukuruzovic RH, Curtis NC, Massie J. Antibiotics for whooping cough (pertussis). Cochrane Database of Systematic Reviews. 2007.

5. Heggie AD, Jaffe AC, Stuart LA, Thombre PS, Sorensen RU. Topical sulfacetamide vs oral erythromycin for neonatal chlamydial conjunctivitis. American Journal of Diseases of Children. 1985;139:564-6.

6. Sandstrom I. Treatment of neonatal conjunctivitis. Arch Ophthalmol. 1987;105:925-8.

7. Stenberg K, Mardh PA. Treatment of chlamydial conjunctivitis in newborns and adults with erythromycin and roxithromycin. J Antimicrob Chemother. 1991;28:301-7.

8. Lee PI, Wu MH, Huang LM, Chen JM, Lee CY. An open, randomized, comparative study of clarithromycin and erythromycin in the treatment of children with community-acquired pneumonia. J Microbiol Immunol Infect. 2008;41:54-61.

9. Ng E, Shah VS. Erythromycin for the prevention and treatment of feeding intolerance in preterm infants. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD001815. DOI: 10.1002/14651858.CD001815.pub2.

10. Oei J, Lui K. A placebo‐controlled trial of low‐dose erythromycin to promote feed tolerance in preterm infants. Acta Paediatrica. 2001 Aug 1;90(8):904-8.

11. Ng SC, Gomez JM, Rajadurai VS, Saw S, Quak S. Establishing enteral feeding in preterm infants with feeing intolerance; A randomized controlled study of low-dose erythromycin. JPGN 2003;37:554–8.

12. Madani A, Pishva N, Pourarian Sh, ZarkeshM. The efficacy of oral erythromycin in enhancement of milk tolerance in premature infants: A randomized controlled trial. Iranian Journal of Medical Sciences 2004;29:1–4.

13. Ng PC, So KW, Fung KSC, Lee CH, Fok TF, Wong E, et al. Randomised controlled study of oral erythromycin for treatment of gastrointestinal dysmotility in preterm infants. Archives of Disease in Childhood. Fetal and Neonatal Edition 2001;84:F177–82.

14. Nuntnarumit P, Kiatchoosakun P, Tantiprapa W, Boonkasidecha S. Efficacy of oral erythromycin for treatment of feeding intolerance in preterm infants. Journal of Pediatrics 2006;148:600–5.

15. Eriksson M, Bolme P, Blennow M. Absorption of erythromycin from pediatric suspension in infants and children. Scandinavian journal of infectious diseases. 1981 Sep 1;13(3):211-5.

16. Murchison L, De Coppi P, Eaton S. Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. Pediatr Surg Int. 2016;32:1147-52.

17. Micromedex. Accessed online 29 May 2018.

18. Curry JI, Lander AD, Stringer MD, Committee BMR. A multicenter, randomized, double-blind, placebo-controlled trial of the prokinetic agent erythromycin in the postoperative recovery of infants with gastroschisis. J Pediatr Surg. 2004;39:565-9.

19. Razzaq A, Safdar CA, Ali S. Erythromycin establishes early oral feeding in neonates operated for congenital intestinal atresias. Pediatric Surgery International. 2009;25:361-4.




Original version Date: 20-6-2018

Author: NeoMed Consensus Group

Current Version number: 1

Current Version Date: 20-6-2018

Risk Rating: Low

Due for Review: 20-6-2023

Approved by: DTC

Approval Date: TBA


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Neonatal Intensive Care Drug Manual

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