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Neonatal Intensive Care Drug Manual
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| bet | 217/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Drug interactions
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Erythromycin: Concurrent use increases the risk of cardiotoxicity (prolonged QT interval, torsades des pointes); therefore avoid combination.
Barbiturates, caffeine, benzodiazepines and phenytoin: Serum concentrations increased by fluconazole, consider dose reduction and therapeutic drug monitoring where available.
Hydrochlorothiazide: Increases fluconazole serum concentration, consider dose reduction of fluconazole.
Zidovudine: Concentrations are increased by fluconazole; monitor for adverse reactions (anaemia, neutropenia) and extend dose interval.
Cisapride: May precipitate arrhythmias, therefore contraindicated.
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