• Practice points References
  • Neonatal Intensive Care Drug Manual




    Download 1,5 Mb.
    bet219/654
    Sana03.01.2022
    Hajmi1,5 Mb.
    #14803
    1   ...   215   216   217   218   219   220   221   222   ...   654
    Special comments

    IV and oral doses are equivalent.

    Evidence

    Treatment dose: 12 mg/kg 24 hourly supported by pharmacokinetic data and Monte Carlo simulations (1,2; Grade B).

    Loading dose: 25 mg/kg loading dose is shown in Monte Carlo simulations to achieve target AUC by day 2 (2; Grade B).

    Post-treatment prophylaxis – expert opinion by Infectious Disease members of the ANMF consensus Group.


    Practice points




    References

    1. Wade KC. et al. (2008) Population Pharmacokinetics of Fluconazole in Young Infants, Antimicrobial Agents and Chemotherapy, vol.52; 11, p. 4043–4049.

    2. Wade KC. et al. (2009) Fluconazole Dosing for the Prevention or Treatment of Invasive Candidiasis in Young Infants, The Paediatric Infectious Disease Journal, vol. 28; 8, 717–723.

    3. Saxen H. et al.(1993) Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of life, Clinical Pharmacology & Therapeutics, vol. 53; 3, 269–277.

    4. Wenzl TG. et al. (1998) Pharmacokinetics of oral fluconazole in premature infants, Eur J Pediatr, 157:661–662.

    5. Nahata MC, Tallian KB, Force RW. Pharmacokinetics of fluconazole in young infants. Eur J Drug Metab Pharmacokinet. 1999;24(2):155–157.

    6. Takemoto CK et al. (2013) Pediatric & Neonatal Dosage Handbook 20th Edition, page 795–798

    7. Trissel’s IV Compatibility, accessed 04/08/2015 via Micromedex 2.0

    8. Society of Hospital Pharmacists of Australia (2015) Australian Injectable Drugs Handbook 6th Edition, Fluconazole Monograph.

    9. MIMs Product Information Fluconazole Sandoz Injection Product Information, Sandoz. MIMS online. Accessed on 13 January 2021

    10. Micromedex solutions. Accessed on 29th July 2015.


    Original version Date: 28/8/2015

    Author: Neonatal Medicines Formulary Consensus Group

    Current Version number: 2

    Version Date: 13/1/2021

    Risk Rating: Low

    Due for Review: 13/1/2026

    Approval by: DTC

    Approval Date: TBA



    Download 1,5 Mb.
    1   ...   215   216   217   218   219   220   221   222   ...   654




    Download 1,5 Mb.

    Bosh sahifa
    Aloqalar

        Bosh sahifa



    Neonatal Intensive Care Drug Manual

    Download 1,5 Mb.