|
Neonatal Intensive Care Drug Manual
|
| bet | 222/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Dosage / Interval
|
IV or PO*: 1 to 2 mg/kg/dose. Dose interval as follows:
Corrected gestational age/Postmenstrual age
|
Interval
|
Preterm infant ≤ 33 weeks
|
Every 24 hours
|
Preterm infant > 33 weeks
|
12–24 hours
|
Term infant 0–30 days
|
Every 12 hours
|
Term infant > 30 days
|
8–12 hours
|
*PO: Dose may be increased up to maximum 6 mg/kg/dose in term infants with heart failure.
IV Infusion: 0.05 to 0.2 mg/kg/hour increased to maximum 0.4 mg/kg/hour if urine output < 1 mL/kg/hour.
Diuresis renography: 1 mg/kg stat.
|
Maximum dose
|
IV: 2 mg/kg/dose
IV infusion: 0.4 mg/kg/hour
Oral: 6 mg/kg/dose
|
Route
|
IV or oral
|
Preparation/Dilution
|
IV bolus: Give undiluted. If dilution required draw up 0.5mL (5 mg of furosemide) and add 9.5mL sodium chloride 0.9% to make a final volume of 10 mL with a concentration of 0.5 mg/mL.
IV infusion:
Single-strength infusion: Draw up 0.5 mL/kg (5 mg/kg of furosemide) and make up to 10 mL with sodium chloride 0.9% or glucose 5% or glucose 10% or glucose 20% to make a 0.5 mg/kg/mL solution. Infusing at a rate of 0.1 mL/hour = 0.05 mg/kg/hour.
Double-strength infusion: Draw up 1 mL/kg (10 mg/kg of furosemide) and make up to 10 mL with sodium chloride 0.9% or glucose 5% or glucose 10% or glucose 20% to make a 1 mg/kg/mL solution. Infusing at a rate of 0.1 mL/hour = 0.1 mg/kg/hour.
Oral: Use as supplied undiluted.
|
Administration
|
IV bolus over 2–4 minutes: maximum rate not to exceed 0.5 mg/kg/minute or 4 mg/minute. For diuresis renography – dose should be given as a push.1
IV infusion: Via syringe pump
Oral: Solution may be administered without regard to feeds.
|
Monitoring
|
Urine output, weight, serum sodium and potassium. Screening for nephrocalcinosis may be required for preterm infants on prolonged therapy.
|
|
|
| |
