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Treatment of hyperglycaemia in very low birth weight infants
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| bet | 319/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Treatment of hyperglycaemia in very low birth weight infants: Systematic review [2] of trials of insulin infusion for treatment of neonatal hyperglycaemia found that use of an insulin infusion obviates the need to decrease the concentration of glucose prescribed and optimised the utilisation of calories by the infant resulting in significant increases in non-protein energy intake, glucose intake and short-term weight gain. However, insulin infusion had no significant effect on death, severe intraventricular haemorrhage, retinopathy of prematurity, bacterial sepsis, fungal sepsis or necrotising enterocolitis; effects on other major morbidities were not assessed. These trials did not report an excess of hypoglycaemia, possibly due to the more liberal target BSLs: Collins 1991 [6] 4.4–9.9 mmol/L and Meetze 1998 [7] 5.5–9.9 mmol/L. Conclusion: Evidence from randomised trials in hyperglycaemic VLBW neonates is insufficient to determine the effects of treatment on death or major morbidities. [2] [LOE I GOR D]
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