• Treatment of hyperkalaemia with insulin—glucose 25% infusion
  • Insulin (Actrapid – for hyperkalemia)




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    Insulin (Actrapid – for hyperkalemia)


    Revision Date : 12-8-2019

    Approved: TC, KOH




    Alert

    High risk of hyperglycaemia and hypoglycaemia.

    Insulin binds to the plastic of giving sets. Flush the plastic tubing with 20 mL of prepared insulin solution into a receptacle prior to connecting to the infant. This is to saturate the binding.

    Insulin concentrations ≤ 0.05 units/mL are not reliably delivered even after preconditioning and flushing.


    Indication


    Treatment of hyperkalaemia:

    • Infants with serum potassium (K+) ≧ 7.0 mmol/L

    • Infants with hyperkalaemia and abnormal ECG

    • Management of severe cardiotoxicity or cardiac arrest due to hyperkalaemia

    Action

    Insulin and glucose activate cellular sodium-potassium ATPase resulting in a potassium shift into the intracellular space.

    Drug Type

    Polypeptide hormone – lowers blood glucose and K+.

    Trade Name

    Actrapid [Novo Nordisk]

    Humulin R [Eli Lilly]

    Hypurin Neutral Injection [Aspen]


    Presentation

    Vial: 100 units/mL in a 10 mL vial.

    Dosage/Interval


    Treatment of hyperkalaemia with insulin—glucose 25% infusion

    Starting dose: 0.1 unit/kg/hour.

    Dose range: 0.05 to 0.2 unit/kg/hour.

    Titrate infusion rate to serial serum potassium and blood glucose concentrations.



    Treatment of hyperkalaemia with insulin-only infusion

    Starting dose: 0.1 unit/kg/hour.

    Dose range: 0.05 to 0.2 unit/kg/hour.

    Titrate infusion rate to serial serum potassium and blood glucose concentrations.




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    Insulin (Actrapid – for hyperkalemia)

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