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Neonatal Intensive Care Drug Manual
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| bet | 326/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Y-site administration: Cefoxitin; chlorpromazine; diazepam; diazoxide; glycopyrronium bromide (glycopyrrolate); isoprenaline; ketamine; labetalol; micafungin; noradrenaline (norepinephrine); phentolamine; phenylephrine; phenytoin; piperacillin sodium-tazobactam sodium; polymyxin; propranolol; protamine; quinidine; rocuronium; sulfamethoxazole-trimethoprim;
Stability
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Actrapid: Prepared solutions are stable at room temperature (< 25°C) for 24 hours.
Humulin R: Prepared infusions can be stored refrigerated for 48 hours and may be used at room temperature for an additional 48 hours.
A 20 mL insulin priming solution at a concentration of 0.1 units per mL was found to deliver 80% of the expected insulin [1].
A 20 mL insulin priming solution with additional preconditioning for 1 hour at a concentration of 0.05 units per mL was found to deliver 26.5% of the expected insulin [2].
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Storage
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Store human insulin preparations between 2 and 8°C. The shelf life is 30 months when stored between 2 and 8°C. Do not freeze. Human insulin preparations which have been frozen must not be used. Protect from excessive heat and light. Should appear clear and colourless. After first use, the vials may be kept at room temperature (below 25°C) for 4 weeks.
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Special Comments
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Recommend administer insulin/glucose in same line as intravenous fluids.
Recommend intravenous fluids and/or an additional glucose 25% syringe placed proximally for rapid treatment of hypoglycaemia if needed.
Do not include insulin in the total daily fluid intake.
Frequent blood glucose and potassium estimations, especially after commencement and during weaning of infusion are needed for titration and safety.
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Evidence summary
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Efficacy
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