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Neonatal Intensive Care Drug Manual
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| bet | 338/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Magnesium
Revision Date : 15-6-2018
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Approved : TC, KOH
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Alert
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1000 mg magnesium sulfate = 98 mg elemental Mg = 4.1 mmol (8 mEq) of elemental Mg.
500 mg magnesium aspartate = 37.4 mg elemental Mg = 1.5 mmol (3 mEq) of elemental Mg.
Intravenous doses should be diluted to a concentration of Mg 20% or less. Calcium chloride/calcium gluconate should be available to reverse adverse effects.
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Indication
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Hypomagnesaemia (acute and chronic).
Pulmonary hypertension when inhaled nitric oxide is not available.
Perinatal asphyxia.
Resuscitation of torsades de pointes.
Neonatal tetany,
Daily maintenance in parenteral nutrition (beyond scope of this guideline).
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Action
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Magnesium is an intracellular cation. Calcium and NMDA receptor antagonist. Magnesium is, necessary for several steps in glycolysis, the Krebs cycle and in protein and nucleic acid, synthesis. It is vital for normal energy storage and transfer. Magnesium plays an important, role in neurochemical transmission, and is essential for proper neurochemical functioning.
Magnesium has an anticonvulsant effect.
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