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Neonatal abstinence syndrome secondary to infant opioid infusion
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| bet | 372/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Neonatal abstinence syndrome secondary to infant opioid infusion:
If weaning from prolonged intravenous morphine (> 4 days), commence oral morphine using the oral:IV ratio of 2:1 (estimated oral morphine bioavailability 48.5% in neonates) [1]. So the daily oral dose is twice the daily intravenous dose of morphine.
If weaning from intravenous fentanyl infusion, we recommend converting the total daily fentanyl dose into the equivalent intravenous morphine dose using the conversion ratio fentanyl:morphine of 1:10 (1 microgram of IV fentanyl is equivalent to 10 microgram of IV morphine) [21]. Convert the intravenous morphine dose to oral morphine dose using the ratio 1:2. That is, oral dose is twice the IV dose.
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