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Neonatal Intensive Care Drug Manual
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| bet | 371/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Morphine Oral
Revision Date : 27-6-2019
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Approved : TC, KOH
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Alert
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S8 – High-risk medication – may cause significant patient harm when used in error.
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Indication
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Analgesia/sedation:
During assisted ventilation
During procedures and post-surgery
Neonatal abstinence syndrome secondary to opioids
Analgesia and relief of dyspnoea including in context of palliative care
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Action
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Opioid analgesic − stimulates the μ-δ-opioid (Mu-Delta) receptor heteromer in the central nervous system.
Modulates neurotransmitters.
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Drug Type
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Opioid analgesic.
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Trade Name
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Ordine (Morphine HYDROCHLORIDE).
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Presentation
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1 mg/mL oral solution of morphine HYDROCHLORIDE.
Also commercially available as 2 mg/mL, 5 mg/mL and 10 mg/mL oral solution.
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Dosage/Interval
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Neonatal abstinence syndrome secondary to maternal opioid dependency:
Starting dose: 0.5 mg/kg/day divided into 4–6 equal divided doses.
Increase dose by 10−25% titrated to Neonatal Abstinence Syndrome scores (aiming for scores < 8) and clinical condition.
Decrease dose by 10–25% every 2–4 days titrated to Neonatal Abstinence Syndrome scores (when scores ≤ 4) and clinical condition.
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