Respiratory: May result in prolonged apnoea or respiratory depression.
Cardiovascular: After administration, approximately 10% of patients may exhibit mild to moderate increases in blood pressure and/or pulse rate. Dysrhythmias may occasionally occur and increased cardiac output is frequently noted.
Hypersensitivity: Hypersensitivity reactions occur rarely (< 1%). Bradycardia, bronchospasm, hypotension and cardiovascular collapse have been reported. An occasional transient rash has been reported. Pruritus can occur, as well as rare cases of flushing, oedema and wheezing.
Skin: A few case reports of local reactions including pain and burning at the site of injection.
Ocular: Pancuronium decreases intraocular pressure and induces miosis.
Neuromuscular: Prolonged paralysis, disuse atrophy and areflexia have been reported with prolonged use of pancuronium.
Other: Hypersalivation may occur, especially if no anticholinergic premedication is given.
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Compatibility
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Fluids: Glucose 5%, glucose 5% in sodium chloride 0.9%, glucose 5% in sodium chloride 0.45%, Hartmann’s, sodium chloride 0.9%.10
Compatible via Y-site : Adrenaline (epinephrine), aminophylline, cefazolin, dobutamine, dopamine, esmolol, fentanyl, fluconazole, gentamicin, glyceryl trinitrate, heparin, hydrocortisone sodium succinate, lorazepam, midazolam, milrinone, morphine, ranitidine, sodium nitroprusside, trimethoprim-sulfamethoxazole, vancomycin.10
Compatible in syringe : Heparin (for 5 minutes).10
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