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Excipients
Special comments
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| bet | 451/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Excipients
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Special comments
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Elimination half-life: In infants 28-41 weeks gestation: Half-life of the drug was estimated (mean+SD) to be 114-2 ± 43.0 h, 73.19 ± 24.17 h and 41.23 ± 13.95 h in patients 1 - 10, 11 - 30 and 31 - 70 days old, respectively; neonates with perinatal asphyxia undergoing hypothermia 173.9±62.5 hours.
Converting from mass units to SI units: 1 mg/L = 4.306 micromol/L.
The general taper recommended for phenobarbital is 10-25% of the original dose every month. A faster taper is recommended for patients on therapy for less than 1 month18
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