• Preparation for hepatobiliary scintigraphy and treatment of neonatal cholestasis
    		•

    Treatment of hyperbilirubinaemia




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    Treatment of hyperbilirubinaemia: A meta-analysis (3 RCTs, 497 infants) found phenobarbital (loading dose 10−30 mg/kg; maintenance 5 mg/kg/day) reduced peak serum bilirubin, duration of and need for phototherapy and need for exchange transfusion in preterm very low birth weight neonates. There are not enough data to evaluate adverse effects and neurodevelopmental outcome (LOE I, GOR C).

    Preparation for hepatobiliary scintigraphy and treatment of neonatal cholestasis: The role of phenobarbital in preparation for hepatobiliary scintigraphy is unclear. [7] (LOE I, GOR C). Phenobarbital may have a role in treatment of pruritis caused by intrahepatic cholestasis.[8]


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