Phenytoin
Revision Date : 16-12-2020
|
Approved : TC, KOH
|
Alert
Rapid IV infusion can cause cardiovascular collapse. Phenytoin concentration is reported in mg/L.
To convert mg/L (microgram/mL) to micromol/L:multiply by 3.964.
Indication
Treatment of neonatal seizures.1-4
Action
Inhibition of neuronal sodium influx, suppression of sodium action-potentials, inhibition of neuronal calcium influx, enhancement of GABA neurotransmission, and blockade of inotropic receptors for glutamic acid.
Drug type
Hydantoin derivative anticonvulsant
Trade name
Dilantin, DBL Phenytoin Injection, Phenytoin Sandoz Injection
Dilantin Paediatric Suspension
Presentation
100 mg/2 mL ampoule
30 mg/5 mL oral suspension
Dose
| 