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Neonatal Intensive Care Drug Manual
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| bet | 481/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Pharmacokinetics
It is primarily excreted via kidneys by glomerular filtration and tubular secretion. Therefore, renal impairment may affect drug elimination. Piperacillin-tazobactam has unreliable CNS penetration and should not used for CNS infections (E.g. meningitis)
Practice points
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Piperacillin - tazobactam can be safely used for treatment of non-CNS systemic infections, necrotising enterocolitis and intra-abdominal infections in very low birth weight infants.(13) (LOE IV, GOR B)
The recommended dose regimen in this formulary is a pragmatic adaptation of the dosing suggested by Cohen-Wolkowiez et al. (3) (LOE IV, GOR B)
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