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Analgesia/sedation for procedures including laser for ROP
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| bet | 505/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Analgesia/sedation for procedures including laser for ROP: A single RCT reports the use of protocol + ketamine compared to inhalational anaesthetic for unventilated infants undergoing laser for ROP. Ulgey et al 2015 [9] compared sedation (n = 30) with ketamine 1 mg/kg + propofol 1 mg/kg as a bolus for induction, then propofol 100–150 microgram/kg/min + ketamine 0.25 mg/kg/h for maintenance, versus general anaesthetic (n = 30) induced using 8% sevoflurane with nitrous oxide 50% in oxygen, then maintained with sevoflurane 2% + nitrous oxide 50% in oxygen. Two patients in the sedation group and 11 patients in inhalational anaesthetic group required postoperative mechanical ventilation. Blood pressures and heart rates were similar. Conclusion: There is insufficient safety and efficacy data for use of propofol infusions as analgesia/sedation in newborns.(LOE II, GOR D)
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