Graph 1 Hypothetical Dose-Response Curve

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tox exposure guidelines (1)
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Graph 1
Hypothetical Dose-Response Curve
Dose-Response Terms. The National Institute for Occupational Safety and Health (NIOSH)
defines a number of general dose-response terms in the "Registry of Toxic Substances" (1983, p.
xxxii). A summary of these terms is contained in Table 1.
• Toxic dose low (TD
LO
): The lowest dose of a substance introduced by any route, other
than inhalation, over any given period of time, and reported to produce any toxic effect in
humans or to produce tumorigenic or reproductive effects in animals.
• Toxic concentration low (TC
LO
): The lowest concentration of a substance in air to
which humans or animals have been exposed for any given period of time that has

(Created 12/02)
UNL Environmental Health and Safety · (402) 472-4925 · http://ehs.unl.edu
produced any toxic effect in humans or produced tumorigenic or reproductive effects in
animals.
• Lethal dose low (LD
LO
): The lowest dose, other than LD
50
of a substance introduced by
any route, other than inhalation, which has been reported to have caused death in humans
or animals.
• Lethal dose fifty (LD
50
): A calculated dose of a substance which is expected to cause the
death of 50 percent of an entire defined experimental animal population. It is determined
from the exposure to the substance by any route other than inhalation.
• Lethal concentration low (LC
LO
): The lowest concentration of a substance in air, other
than LC
50
, which has been reported to cause death in humans or animals.
• Lethal concentration fifty (LC
50
): A calculated concentration of a substance in air,
exposure to which for a specified length of time is expected to cause the death of 50
percent of an entire defined experimental animal population.

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