• Table 1 . • Toxic dose low (TD LO )
  • Toxic concentration low (TC LO )
  • Lethal dose low (LD LO )
  • Lethal concentration low (LC LO )
  • Graph 1  Hypothetical Dose-Response Curve




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    tox exposure guidelines (1)

    Graph 1 
    Hypothetical Dose-Response Curve 
    Dose-Response Terms. The National Institute for Occupational Safety and Health (NIOSH) 
    defines a number of general dose-response terms in the "Registry of Toxic Substances" (1983, p. 
    xxxii). A summary of these terms is contained in Table 1.
    Toxic dose low (TD
    LO
    ): The lowest dose of a substance introduced by any route, other 
    than inhalation, over any given period of time, and reported to produce any toxic effect in 
    humans or to produce tumorigenic or reproductive effects in animals.
    Toxic concentration low (TC
    LO
    ): The lowest concentration of a substance in air to 
    which humans or animals have been exposed for any given period of time that has 


    (Created 12/02) 
    UNL Environmental Health and Safety · (402) 472-4925 · http://ehs.unl.edu 
    produced any toxic effect in humans or produced tumorigenic or reproductive effects in 
    animals.
    Lethal dose low (LD
    LO
    ): The lowest dose, other than LD
    50
    of a substance introduced by 
    any route, other than inhalation, which has been reported to have caused death in humans 
    or animals.
    Lethal dose fifty (LD
    50
    ): A calculated dose of a substance which is expected to cause the 
    death of 50 percent of an entire defined experimental animal population. It is determined 
    from the exposure to the substance by any route other than inhalation.
    Lethal concentration low (LC
    LO
    ): The lowest concentration of a substance in air, other 
    than LC
    50
    , which has been reported to cause death in humans or animals.
    Lethal concentration fifty (LC
    50
    ): A calculated concentration of a substance in air, 
    exposure to which for a specified length of time is expected to cause the death of 50 
    percent of an entire defined experimental animal population.

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    Graph 1  Hypothetical Dose-Response Curve

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