• TABLE 3 Toxicity Rating Toxicity Rating or Class Oral Acute LD 50 for Rats
  • TABLE 4 LD 50 Values for Rats for a Group of Well-Known Chemicals Chemical LD 50 (mg/kg)
    		•

    Establishing Exposure Guidelines




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    tox exposure guidelines (1)
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    Establishing Exposure Guidelines. Toxicity data from both animal experimentation and 
    epidemiological studies is used to establish exposure guidelines. The method for deriving a 
    guideline is dependent upon the type of chemical as well as duration and frequency of exposure. 
    It is also important to make the distinction between an experimental dose (mg/kg) and an 
    environmental concentration (mg/m
    3
    or ppm). In order to make safety decisions, exposure 
    guidelines are presented as concentrations so that these values can be compared to concentrations 
    measured by air monitoring instrumentation.
    TABLE 3 
    Toxicity Rating 
     Toxicity Rating or Class
    Oral Acute LD
    50
     for Rats
    Extremely toxic
    1 mg/kg or less (dioxin, botulinum toxin) 
    Highly toxic
    1 to 50 mg/kg (strychnine) 
    Moderately toxic
    50 to 500 mg/kg (DDT) 
    Slightly toxic
    0.5 to 5 g/kg (morphine) 
    Practically nontoxic
    5 to 15 g/kg (ethyl alcohol) 
    TABLE 4 
    LD
    50
     Values for Rats for a Group of Well-Known Chemicals 
     Chemical
    LD
    50
     (mg/kg)
    Sucrose (table sugar)
    29,700 
    Ethyl alcohol
    14,000 
    Sodium chloride (common salt)
    3,000 
    Vitamin A
    2,000 
    Vanillin
    1,580 
    Aspirin
    1,000 
    Chloroform
    800 

    (Created 12/02) 
    UNL Environmental Health and Safety · (402) 472-4925 · http://ehs.unl.edu 
    Copper sulfate
    300 
    Caffeine
    192 
    Phenobarbital, sodium salt
    162 
    DDT
    113 
    Sodium nitrite
    85 
    Nicotine
    53 
    Aflatoxin B1
    7 
    Sodium cyanide
    6.4 
    Strychnine
    2.5 

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