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Neonatal Intensive Care Drug Manual
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| bet | 141/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Concurrent use with beta-blockers.
Acute stage of necrotising enterocolitis (NEC).
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Precautions
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To minimise systemic absorption, apply pressure over the nasolacrimal sac for 2 to 3 minutes following instillation.
Bronchopulmonary dysplasia.
Feeding intolerance.
Severe neurological impairment.
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Drug interactions
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Propranolol: An enhanced pressor response to phenylephrine has been shown in patients on propranolol (blocks the beta-adrenergic vasodilation that normally reduces the blood pressure effect).
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Adverse reactions
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These usually only occur with excess dosing.
Anticholinergic side effects include fever, tachycardia, vasodilation, dry mouth, restlessness, delayed gastric emptying and decreased gastrointestinal motility, and urinary retention.
Alpha-adrenergic side effects include decreased pulmonary compliance, tidal volume and peak airflow in babies with bronchopulmonary dysplasia.
Increased heart rate and blood pressure.
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Compatibility
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N/A
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Incompatibility
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N/A
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Stability
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Single use only. Discard after use.
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Storage
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Store at room temperature < 25°C.
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Excipients
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Preservative: Benzalkonium chloride 0.01%. Inactives: Edetate disodium, boric acid, hydrochloric acid and/or sodium carbonate (to adjust pH), purified water.
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