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Neonatal Intensive Care Drug Manual
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| bet | 166/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Digoxin
Revision Date : 15-12-2020
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Approved : TC, KOH
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Alert
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Digoxin has a narrow therapeutic index, check the dose carefully.
Lanoxin adult injection is 10 times more concentrated than Lanoxin infant injection. Check product selection carefully.
Rapid IV injection may cause hypertension and reduced coronary flow.
Lanoxin Paediatric Elixir contains ethanol of approximately 84 mg/mL, equivalent to 10.6% absolute volume. The long-term effects of prolonged exposure to ethanol content from medicines have not been studied.
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Indication
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Supraventricular tachycardia [atrioventricular reciprocating tachycardia or atrioventricular nodal re-entrant tachycardia, excluding Wolff-Parkinson-White]
Atrial fibrillation and atrial flutter
Heart failure [add-on treatment in infants with reduced ejection fraction if not otherwise contraindicated].
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Action
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Slows heart rate and reduces AV nodal conduction by an increase in vagal tone and a reduction in sympathetic activity. A Na+/K+-ATPase inhibitor which increases the force of myocardial contraction by increasing the release and availability of stored intracellular calcium.
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