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Neonatal Intensive Care Drug Manual
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| bet | 164/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Special comments
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Concomitant use of a thiazide diuretic is recommended to counter sodium and fluid retention from use of diazoxide.4, 5
Oral diazoxide preparations are not registered in Australia. Complete a Special Access Scheme - Category C form and obtain parental consent.
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Evidence
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Efficacy: There are no clinical trials of diazoxide for management of hyperinsulinaemic hypoglycaemia. Transient and syndromic hyperinsulinaemic hypoglycaemia tends to be diazoxide responsive, whereas other genetic forms affecting the K-ATP channel and incretin receptors, and infants with insulinomas, are variably responsive.2-4, 6-9 (LOE IV, GOR C)
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