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Neonatal Intensive Care Drug Manual
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| bet | 160/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Diazoxide
Revision Date : 15-12-2020
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Approved : TC, KOH
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Alert
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Concomitant use of a thiazide diuretic is recommended. Avoid higher dose where possible.
Proglycem 50mg/mL suspension contains alcohol 7.25%. Oral solution prepared by Pharmacy is preferred.
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Indication
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Treatment of transient or persistent neonatal hyperinsulinaemic hypoglycaemia.
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Action
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Opens potassium-ATP channels on pancreatic beta-cells to inhibit insulin secretion. Also occurs in cardiac and vascular smooth muscle leading to decrease in blood pressure and potential for cardiorespiratory deterioration.
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Drug type
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Antihypertensive, antidiuretic benzothiadiazine.
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Trade name
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Oral: Proglycem suspension, Proglicem capsules
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Presentation
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Oral: 10 mg/mL solution (prepared by Pharmacy using Proglicem 25mg or 100mg capsules); Proglycem 50 mg/mL oral suspension is commercially available as an unregistered product.
IV preparations are available but beyond the scope of this formulary. Discuss with specialist.
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Dose
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2–5 mg/kg/dose every 8 hours OR
2.5–7.5 mg/kg/dose every 12 hours.
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