Avoid sodium and water overload.
Concomitant use of a thiazide diuretic is recommended.
Avoid higher doses where possible.
Use with caution in premature infants – increased risk of cardiorespiratory complications.
Use with caution in jaundice – may displace bilirubin from albumin.
Reduce dose in infants with renal impairment.
Use with caution in infants with hepatic impairment.
Use with caution in mechanical hypertension, e.g. secondary to aortic coarctation or arteriovenous shunt.
Use with caution in pulmonary hypertension.
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