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Neonatal Intensive Care Drug Manual
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| bet | 183/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Dobutamine IV Infusion
Revision Date : 18-2-2021
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Approved : TC, KOH
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Alert
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In conditions with low systemic vascular resistance (SVR) (e.g., septic shock) dobutamine is not the appropriate first drug of choice
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Indication
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Inotrope to increase cardiac output in neonates with myocardial dysfunction and unchanged or increased systemic vascular resistance.
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Action
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Catecholamine with beta-1 and beta-2 receptor actions which increases myocardial contractility, heart rate and conduction velocity and decreases SVR 1.
Dose dependent effects:
• Low dose, 2.5 microgram/kg/min – no significant hemodynamic effects in neonates with cardiovascular compromise
• Moderate dose, 5–7.5 microgram/kg/min – increases cardiac output
• Higher dose, 5–20 microgram/kg/min – increases cardiac output and blood pressure in hypotensive preterm infants
An additional effect of dobutamine on increasing cardiac output has been demonstrated in hypotensive preterm infants receiving dopamine.
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