Dipyridamole was shown to produce a fourfold increase in adenosine activity. Dipyridamole should be discontinued 24 hours beforehand or the dose of adenosine should be significantly reduced.
Adenosine may interact with drugs that tend to impair cardiac conduction. Aminophylline, theophylline and caffeine are competitive adenosine antagonists and should be avoided for 24 hours prior to the administration of adenosine.
Adenosine has been effectively administered in the presence of other cardioactive drugs, such as digitalis, quinidine, beta-adrenergic blocking agents, calcium channel blocking agents and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile.
|
