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Neonatal Intensive Care Drug Manual
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| bet | 232/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Hypersensitivity to ganciclovir, valganciclovir, aciclovir or valacyclovir.
Patients with:
absolute neutrophil count below 0.5 x 109/L or
platelet count below 25 x 109/L unless thrombocytopenia is related to CMV disease, or
haemoglobin less than 80 g/L (8 g/dL).
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Precautions
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Ganciclovir has both gonadal toxicity and carcinogenicity in animal models and its long-term safety after administration to young children is not established.1
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Drug interactions
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Convulsions have been reported in patients receiving ganciclovir and imipenem-cilastatin concurrently.
Concurrent use of tacrolimus and ganciclovir increases nephrotoxicity.
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