• Compatibility
  • Incompatibility
  • Time Since Last Heparin Dose




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    Time Since Last Heparin Dose

    Protamine dose per 100 units of heparin received in the last 2 hours

    <30 min

    1 mg

    30-60 min

    0.5-0.75 mg

    60-120 min

    0.375-0.5 mg

    >120 min

    0.25-0.375 mg

    Maximum dose of 50 mg. Infusion rate of a 10 mg/mL solution should not exceed 5 mg/min. Hypersensitivity reactions to protamine sulfate may occur in patients with known hypersensitivity reactions to fish or those previously exposed to protamine therapy or protamine-containing insulin. For more information, refer to Protamine formulary.

    Compatibility

    Fluids: Glucose 5%, Sodium chloride 0.9%.9

    Y-site: Aciclovir, ampicillin, atropine, aztreonam, caffeine citrate, calcium chloride, calcium gluconate, cefazolin, cefotaxime, clindamycin, dexamethasone, dexmedetomidine, digoxin, dopamine, ephedrine sulfate, fentanyl, fluconazole, folic acid (sodium salt), furosemide, hydrocortisone sodium succinate, levetiracetam, linezolid, magnesium sulfate, meropenem, metronidazole, midazolam hydrochloride, morphine sulfate, naloxone hydrochloride, noradrenaline, pancuronium bromide, paracetamol, piperacillin/tazobactam, phenobarbital sodium, pipercillin-tazobactam, potassium chloride, rocuronium bromide, suxamethonium, vecuronium, zidovudine.



    Incompatibility

    Fluids: Fat emulsion

    Y-site: Benzylpenicillin, ciprofloxacin, cisatracurium, dobutamine, erythromycin, gentamicin, ketamine, tobramycin




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