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Neonatal Intensive Care Drug Manual
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| bet | 272/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Hydrocortisone
Revision Date : 15-3-2018
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Approved: TC, KOH
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Alert
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Oral dose: Hydrocortisone is not soluble in water and the dose is not evenly distributed in the solution. Refer to preparation section for specific instructions on the oral preparation.
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Indication
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Treatment of cortisol deficiency (hypoadrenalism).
Treatment of hypotension NOT responding to inotrope.
Short term adjunctive therapy for persistent hypoglycaemia.
Prevention of bronchopulmonary dysplasia (not routinely recommended)
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Action
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Adrenal corticosteroid with primarily glucocorticoid effects.
Enhances vascular reactivity to other vasoactive substances by increasing expression of adrenergic receptors in the vascular wall and increasing calcium concentrations in myocardial cells.
Decreases breakdown of catecholamines.
Stimulates the liver to produce glucose from amino acids and glycerol, and stimulates the deposition of glucose as glycogen.
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