Neonatal Intensive Care Drug Manual

A full course of ibuprofen may not be necessary if ductal constriction or closure is demonstrated [1,2].

A repeat course of treatment may be considered depending on continuing haemodynamic significance of the ductus arteriosus and relative contraindications to treatment [3]. Data are insufficient to determine the efficacy of a 3^rd course [4].

Therapeutic hypothermia

ECMO

Renal impairment

Not applicable

Not applicable

Current evidence is insufficient to suggest any specific dose adjustment.

Not applicable

Can be administered undiluted.

If dilution is required draw up 2 mL (10 mg of ibuprofen) and add 2 mL of sodium chloride 0.9% or glucose 5% to make a final volume of 4 mL with a concentration of 2.5 mg/mL.
Neoprofen (ibuprofen lysine)

Draw up 1 mL (10 mg of ibuprofen) and add 3 mL of sodium chloride 0.9% or glucose 5% to make a final volume of 4 mL with a concentration of 2.5 mg/mL.

Draw up 0.5 mL (50 mg of ibuprofen) and add 19.5 mL of sodium chloride 0.9% or glucose 5% to make a final volume of 20 mL with a concentration of 2.5 mg/mL.

Pedea − over 15 minutes.

Neoprofen − over 15 minutes

Caldolor − over 30 minutes