Diuretics – Ibuprofen may reduce the effect of diuretics; whilst the diuretic may increase the risk of nephrotoxicity of NSAIDs in dehydrated patients.
Anticoagulants – ibuprofen may increase the effect of anticoagulants and enhance the risk of bleeding.
Nitric oxide – as both medicinal products have an inhibitory effect on platelet function, their combination may in theory increase the risk of bleeding.
Corticosteroids – ibuprofen may increase the risk of gastrointestinal bleeding.
Other NSAIDs – the concomitant use of more than one NSAID may increase risk of adverse reactions.
Aminoglycosides – since ibuprofen may decrease the clearance of aminoglycosides, their co-administration may increase the risk of nephrotoxicity and ototoxicity.
Fluconazole - Metabolism of ibuprofen may be inhibited, increasing its concentration.
Systemic corticosteroids - Intestinal perforation has been described in infants treated with early dexamethasone and indomethacin. Although not described with ibuprofen, caution is advised.
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