Neonatal Intensive Care Drug Manual

Because most term infants and children with PDA are asymptomatic, acute medical treatment before definitive closure is usually not necessary. Those with symptoms usually improve with a standard short term regimen of fluid restriction and diuretics. [11,12] Indomethacin has been reported to constrict the ductus in case series of term infants with PDA (25/41; 61%) and infants with genetic disorders and/or congenital abnormality (67/85; 79%). [12,13] There are no reports of use of ibuprofen for treatment of a PDA in term infants.