Immunoglobulin IV (Intragram®P)

This formulary is for Intragam 10.

Intragam 10 is the domestically produced intravenous immunoglobulin (IVIg) and is the most likely product that you will receive from the Australian Blood Service.

Intragam P (6%) is no longer produced as of June 2018.

Flebogamma 5% and 10% should not be given to neonates due to undiagnosed hereditary fructose intolerance.

Other preparations such as Privigen 10 are available for paediatric use, but beyond the scope of this formulary.

1. 
   Neonatal alloimmune thrombocytopenia (NAIT)
   
2. 
   Haemolytic disease of the newborn (HDN) (isoimmunisation)
   
3. 
   Immune thrombocytopenic purpura
   
4. 
   Primary immunodeficiency diseases
   
5. 
   Secondary hypogammaglobulinaemia
   
6. 
   Neonatal haemochromatosis – gestational alloimmune liver disease (GALD)
   
7. 
   Neonatal myasthenia gravis
   
8. 
   Severe neonatal enterovirus infection including myocarditis or hepatitis
   
9. 
   Sepsis/infection – prevention and treatment – NOT RECOMMENDED.
   

1, 3-5, and 7 are approved indications by the National Blood Authority of Australia, 6 is a proposed addition as of June 2018.

See https://www.criteria.blood.gov.au/ for a comprehensive list.

Indications not funded under the Criteria for the clinical use of intravenous immunoglobulin in Australia (Criteria), may be provided for locally under Jurisdictional Direct Orders (https://www.blood.gov.au/system/files/documents/jdo-factsheet.pdf).