Medical officer should prescribe (1) brand of IVIg and the % concentration (e.g. Intragam 10), (2) dose in grams and the volume in mL (e.g. 2 g/20 mL) and (3) Rate of infusion (see Administration section)
Isoimmunisation:
1 g/kg (range 0.5–1.5 g/kg) IV. Dose may be repeated in 12–24 hours if required.
Neonatal alloimmune thrombocytopenia (NAIT):
1 g/kg IV. Repeat if required.
Immune thrombocytopenic purpura (ITP):
1 g/kg IV. Repeat if required.
Immunodeficiency:
0.4 g/kg IV (dose should be based on number of infections and trough serum IgG concentration [optimally above 6 g/L, higher if there is bronchiectasis]).
Neonatal myasthenia gravis:
1 g/kg IV daily for 2 days (total dose: 2 g/kg). If additional therapy required, titrate against clinical response.[9]
Severe enterovirus infection/myocarditis or hepatitis:
2 g/kg IV (up to 2.5 g/kg) as a single dose within 3 days of onset.
Sepsis/infection (prevention or treatment) – not recommended:
0.5 to 1 g/kg IV repeated at intervals when required has been used.
Neonatal haemochromatosis:
1–2 g/kg/day IV following exchange transfusion in the first 7 days and then 1 g/kg weekly, as required.
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