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Neonatal Intensive Care Drug Manual
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| bet | 343/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Heart block or myocardial damage.
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Precautions
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Use with caution in renal impairment.
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Drug Interactions
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Concurrent use with paralysing agents may enhance neuromuscular blockade (e.g. succinylcholine, vecuronium, rocuronium, etc)
Concomitant use with aminoglycosides may cause neuromuscular weakness (respirator arrest).
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Adverse Reactions
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Hypotension, bradycardia and circulatory collapse with rapid infusion.
ECG changes (prolonged AV conduction time, sino-atrial block, AV block). Calcium chloride/calcium gluconate should be available to reverse adverse effects. Flushing, sweating, respiratory depression (particularly with higher plasma concentrations) abdominal distension, diarrhoea, urinary retention, CNS depression, muscle relaxation,
hyporeflexia.
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Compatibility
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Sodium chloride 0.9%, sodium chloride 0.45%/glucose 4%, glucose 5%, parenteral nutrition, glucose amino acid solution.
Y site: Aciclovir, amifostine, amikacin, ampicillin, aztreonam, bivalirudin, caspofungin, cefotaxime, cefoxitin, cefazolin, chloramphenicol, cisatracurium, dexmedetomidine, doripenem, esmolol, gentamicin, granisetron, heparin sodium, hydrocortisone sodium, succinate, labetalol, linezolid, metronidazole, milrinone, morphine sulfate, piperacillin-tazobactam (EDTA-free), potassium chloride, remifentanil, sodium nitroprusside, trimethoprim-sulfamethoxazole, vancomycin.
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Incompatibility
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Fat emulsion. Incompatible with soluble phosphates and with alkaline carbonates and, bicarbonates.
Y site: Aminophylline, amiodarone, anidulafungin, azathioprine, calcium chloride, calcium, salts, cefepime, ceftriaxone, ciprofloxacin, clindamycin, cyclosporin, dexamethasone, ganciclovir, haloperidol lactate, indometacin, methylprednisolone sodium succinate,
pentamidine, phosphate salts, sodium bicarbonate.
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Stability
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Change the IV preparation every 24 hours.,
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Storage
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Store at room temperature and protect from light.
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