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Neonatal Intensive Care Drug Manual
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| bet | 391/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Noradrenaline
Revision Date : 24-12-2020
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Approved: TC, KOH
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Alert
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Prescribe as noradrenaline base. Noradrenaline acid tartrate 2 mg/mL is equivalent to noradrenaline base 1 mg/mL (1:1,000)
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Indication
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Treatment of hyperdynamic shock secondary to sepsis. [1]
Second line inotrope for treatment of fluid-refractory hypotensive shock in the setting of low systemic vascular resistance (SVR).[1]
Circulatory failure in the setting of pulmonary hypertension refractory to nitric oxide.[2]
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Action
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Catecholamine with strong vascular alpha and cardiac beta-adrenergic action, moderate cardiac alpha-adrenergic actions.[3]
Noradrenaline increases blood pressure, urine output and reduces lactate in newborns with septic shock refractory to volume expansion and other inotropes.[4]
Noradrenaline increases systemic and pulmonary pressures, increases pulmonary blood flow and improves systemic oxygen saturation in newborn infants with pulmonary hypertension and circulatory failure. [2]
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