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Neonatal Intensive Care Drug Manual
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| bet | 438/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Adverse reactions
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Vomiting, fever, rash, neutropenia, leucopoenia, thrombocytopenia. May cause liver toxicity at high plasma concentrations.
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Compatibility
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Sodium chloride 0.9%, glucose 5%
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Incompatibility
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Do not mix with any other intravenous fluids or medications.
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Stability
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Vials should be used immediately after opening. Any unused solution should be discarded. After dilution in 0.9% sodium chloride or 5% glucose do not store for more than 1 hour (infusion time included).
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Storage
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IV: Do not store above 30°C. Do not refrigerate or freeze.
Oral: Store below 25°C.
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Special comments
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Preterm infants may be at increased risk of paracetamol toxicity. Review indications if IV paracetamol is needed for more than 48 hours.
Antidote of choice for overdose is acetylcysteine IV infusion.
Rectal bioavailability is variable depending on the formulation used. Oral or intravenous routes are preferred.
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Evidence
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