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Neonatal Intensive Care Drug Manual
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| bet | 467/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Dosage/Interval
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Treatment of metabolic bone disease (MBD)
PO: 1 to 3 mmol/kg/day in 2-4 divided doses as an addition to intake from milk and other sources to a maximum intake of 4.5 mmol/kg/day.
Use either Sodium dihydrogen phosphate Phebra IV preparation or Phosphate-Sandoz tablets.
General principles of treatment of MBD:
Commence at low dose (e.g. 1 mmol/kg/day) and titrate the dose up as tolerated.
Given in conjunction with calcium supplementation (but not together - example: Calcium 8 AM, 2 PM, 8 PM and Phosphorus 6 AM, 12 MD, 6 PM )
Aim to reach the upper end of the recommended intake: Ca 5 mmol/kg/day and P 4.5 mmol/kg/day.8
Dose can be adjusted with a goal of slight excess supply aiming for urinary calcium ≥1.2mmol/L and phosphate ≥0.4 mmol/L.
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