• Premedication for MIST or InSurE procedures*
  • Maximum daily dose Premedication: 6 mg/kg. Route
  • Administration
  • Neonatal Intensive Care Drug Manual




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    Dosage / Interval

    Premedication for endotracheal intubation*

    IV: Start at 1 mg/kg and titrate dose of 2.5 mg/kg to infant response (check eye lash reflex every 10 seconds – average ranging from 1.0 to 3.6 mg/kg.


    Premedication for MIST or InSurE procedures*

    IV 1 mg/kg (maximum 1.5 mg/kg) (CAUTION: Increases the chance of needing non-invasive respiratory support).



    *NOTE: Propofol may be used alone or in combination with other sedatives/analgesics. Reduce propofol dose by 40–60% if combined with other sedatives/analgesics.


    Maximum daily dose

    Premedication: 6 mg/kg.

    Route

    IV bolus

    Preparation/Dilution

    Use undiluted or dilute to a minimum concentration of 2 mg/mL with glucose 5%.


    Administration

    Slow IV bolus over at least 20 seconds.

    Do not use filter.20




    Monitoring

    Continuous cardiorespiratory monitoring.

    Resuscitation facilities must be readily available.



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    Neonatal Intensive Care Drug Manual

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