Neonatal Intensive Care Drug Manual

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Presentation
IV 500mg/100mg vial (500 mg of amoxicillin and 100 mg of clavulanic acid) [5:1 ratio], 1000mg/200mg vial (1000 mg of amoxicillin and 200 mg of clavulanic acid) [5:1 ratio]., Vials containing alternative ratios have not been included in this formulary. Oral Reconstituted suspension (125 mg amoxicillin and 31.25 mg clavulanate per 5 mL) [4:1 ratio].
Dosage/Interval	Doses are based on amoxicillin component IV: 25 mg (of amoxicillin component)/kg/dose, 12 hourly. [1-4] Oral: 15-20 mg (of amoxicillin component)/kg/dose, 12 hourly. [5]
Dose adjustment	Therapeutic hypothermia: Insufficient information to recommend any specific dose adjustment. ECMO: 25 to 50 mg/kg every 6 hours in paediatric intensive care patients after cardiac surgery may not, be adequate. Renal impairment: Consider alternate antibiotic in moderate to severe renal impairment. Hepatic: No dose adjustment required. Monitor hepatic function closely. [3]

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