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Neonatal Intensive Care Drug Manual
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| bet | 55/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Drug Interactions
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Warfarin: increased risk of bleeding.
Tetracycline: reduction of efficacy.
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Adverse Reactions
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Mucositis, oral candidiasis, mild to life-threatening Clostridium difficile-associated diarrhoea, life-threatening hepatic dysfunction, and skin rashes including Stevens-Johnson syndrome, Toxic epidermal necrolysis and severe hypersensitivity reactions such as anaphylaxis have been reported.
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Compatibility
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Fluids: sodium chloride 0.9%, glucose 5% (by Y-site only), Hartmann’s, Ringer’s.
Y-site: No information.
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Incompatibility
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Fluids : Glucose 5%,
Drugs: amikacin, gentamicin, tobramycin, amiodarone, ciprofloxacin, metronidazole, sodium, bicarbonate.
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Stability
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IV: the reconstituted solution is stable for 20 minutes at 25 °C. Diluted IV solution: stable in sodium, chloride 0.9% for 4 hours and in Hartmann's and Ringer's for 3 hours at 25 °C. Stable in sodium chloride, 0.9% for 8 hours at 2 to 8 °C when added to a pre-refrigerated bag.
Oral: The medication mixed with milk should be administered immediately., ,
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Storage
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Vial: store below 25 °C. Protect from light.
Oral: Store dry powder for oral suspension at 20 to 25°C. Store reconstituted suspension at 2 to 8 °C. Discard unused suspension after 7 days.
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Excipients
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Oral,
Curam Powder for Suspension: Lemon Flavouring , Peach-Apricot Flavouring, citric acid, sodium citrate, aspartame, purified talc, Orange Flavouring, Guar Gum and silicon dioxide. Contains sulfites. When, reconstituted as directed, Curam 125/31.25 contains aspartame 8.5mg/5mL. Each 5mL of suspension, contains 0.16mmol of potassium.
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