• Indication Analgesia –relief of pain for infants undergoing minor procedures. Action
  • Presentation 24% sucrose oral solution 1 mL. Dosage / Interval
  • Route Oral Administration
  • Neonatal Intensive Care Drug Manual




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    Sucrose


    Revision Date : 2-3-2021

    Approved: TC, KOH




    Alert

    Sucrose for this purpose is a medication and needs to be prescribed and documented on the medication chart.

    Indication

    Analgesia –relief of pain for infants undergoing minor procedures.

    Action

    Orally mediated increase in endogenous opioids.

    Trade Name

    Sucrose Oral Solution 24% (Phebra)

    SweetUms 24% Sucrose (Atris)



    Presentation

    24% sucrose oral solution 1 mL.

    Dosage / Interval

    0.012–0.12 g (0.05–0.5 mL of 24% Sucrose)
    There are no published dose limits per day. There is a lack of long-term safety data in infants. Avoid excess usage in extreme to very preterm infants < 31 weeks post-conceptual age (suggested maximum 1 mL cumulative dose per 24 hours).

    Route

    Oral

    Administration

    Administer onto buccal mucosa – under tongue or anterior tongue toward cheek.

    Do not administer directly into the stomach via an intra-gastric tube.

    Two minutes prior to the painful procedure, administer a small volume of sucrose onto the anterior aspect of the infant’s tongue.

    Offer a pacifier if this is part of the infant’s care. Encourage non-nutritive sucking, as it may increase the pain relief effect.

    On commencement of the painful procedure, give another small volume to the infant.

    Continue to administer small volumes every 2 minutes or more frequently as required.



    Monitoring

    Monitor for signs of gagging and choking. Monitor for effectiveness — reduction in behavioural and physiological signs of pain.


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    Neonatal Intensive Care Drug Manual

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