Anaphylaxis: Severe anaphylactic reactions (some life-threatening and fatal) have been reported. Cross-sensitivity with other neuromuscular-blocking agents may occur; use extreme caution in patients with previous anaphylactic reactions.
Bradycardia: May increase vagal tone. Risk of bradycardia may be increased with second dose and may occur more often in children. Occurrence may be reduced by pre-treating with anticholinergic agents (e.g. atropine).
May Increase intraocular pressure.
May cause a transient increase in intracranial pressure.
May increase intragastric pressure, which could result in regurgitation and possible aspiration of stomach contents.
Malignant hyperthermia: Use may be associated with acute onset of malignant hyperthermia; risk may be increased with concomitant administration of volatile anaesthetics.
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