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Neonatal Intensive Care Drug Manual
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| bet | 586/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Drug Interactions
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May enhance the effect of other agents with neuromuscular-blocking properties: acetylcholinesterase inhibitors; magnesium, quinidine, quinine, vancomycin, cyclophosphamide monohydrate, ciclosporin, esmolol, lincosamide, loop diuretics.
Aminoglycosides: May enhance the respiratory depressant effect of aminoglycosides.
Opioid analgesics: Suxamethonium may enhance the bradycardic effect of opioid analgesics.
Cardiac glycosides: May enhance the arrhythmogenic effect of cardiac glycosides
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Adverse Reactions
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Bradycardia is common in neonates and children, especially after a second dose of suxamethonium. May be prevented by administration of atropine prior to administration of suxamethonium.
Hyperkalaemia
Prolonged paralysis in infants with deficiency of pseudocholinesterase.
Hypersensitivity reactions
Malignant hyperthermia
Management of suxamethonium overdose and/or toxicity is supportive.
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Compatibility
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Dextrose 5%, dextrose 10%, sodium chloride 0.9%, dextrose 5% in sodium chloride 0.9%, dextrose 5% in sodium chloride 0.45%, sodium chloride 0.45%.
Y-site administration: potassium chloride, propofol, vitamin B complex with C.
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